.4-Acetoxy-N,N-dimethyltryptamine (also known as 4-AcO-DMT, 4-Acetoxy-DMT, O-Acetylpsilocin, and psilacetin) is a novel psychedelic substance of the tryptamine class. It is chemically similar to psilocybin, the active ingredient in psilocybin mushrooms (magic mushrooms). It belongs to a group known as the substituted tryptamines which act by stimulating serotonin receptorsin the brain. Buy 4-AcO-DMT in USA 4-AcO-DMT Buy
The synthesis of 4-AcO-DMT was first reported in 1963 by Albert Hofmann and Franz Troxler. However, its properties were not examined and no further studies were carried out. A 1999 paper by David E. Nichols suggested it as a useful alternative to psilocybin for pharmacological research. Reports of human use began to surface following its appearance on the online research chemical market in the 2010s. Buy 4-AcO-DMT in USA
User reports indicate that the subjective effects of 4-AcO-DMT are near identical to those of psilocybin mushrooms.. Characteristic effects include geometric visual hallucinations, time distortion, enhanced introspection, and ego loss. 4-AcO-DMT’s classical psychedelic effects and favorable tolerability profile has led it to become popular among novel psychoactive substance users. Particularly those seeking mystical-like or entheogenic experiences.
In the body O-acetylpsilocin is decelerated to psilocin by deacetylases / acetyltransferases during first pass metabolism and during subsequent passes through the liver (evident as psilacetin is also active via par-enteral routes of ingestion).
Claims of subjective differences in effect between the acetylated and non-acetylated forms of psilocin differ: some users report that O-acetylpsilocin lasts slightly longer while others report that it lasts for a considerably shorter time. Many users report less body load and nausea compared to psilocin.
Some users find that the visual distortions produced by O-acetylpsilocin more closely resemble those produced by DMT than those produced by psilocin. These differences could be possible if psilacetin is active itself and not merely as a prodrug. Despite this, there have been no controlled clinical studies to distinguish any effects of psilacetin, psilocin, and psilocybin from one another.